South America

An incredible mix of old and new, South America has it all from the relics of ancient civilisations to more modern, colonial histories; dramatic fjords and mountains contrast with vibrant, modern cities before giving way to tropical rainforests and massive, winding rivers.

An incredible mix of old and new, South America has it all from the relics of ancient civilisations to more modern, colonial histories; dramatic fjords and mountains contrast with vibrant, modern cities before giving way to tropical rainforests and massive, winding rivers. Cruises to South America can travel down the west coast from Los Angeles or Santiago or Miami, travelling down the east or west coast & around Cape Horn, or taking shorter voyages to just a few ports of call. Other destinations in South America include the unspoiled Galapagos Islands and the mighty Amazon river.

When to Visit?
The season for South America cruises is predominantly the northern winter, October to April. The temperature can reach up to 60F and increases towards the equator. The climate for the Amazon is hot and humid.

Discover more about South America Cruises

You can reach the west coast of South America from Los Angeles, Miami or even from the UK as part of a longer world or exotic cruise. Call into the high Andes capital of Ecuador Quito from the port of Manta and Lima from Callao to visit the remains of pre-Inca and Inca civilisations including the world-famous citadel of Machu Picchu. Calling onto Arica or Iquique you can visit the Atacama Desert of northern Chile. From Quito it is possible to fly to the legendary Galapagos Islands and cruise all the major islands here, to see up close and personal some of the most extraordinary wildlife on earth.

Sailing between stately Buenos Aires and Santiago in Chile, visit the Chilean Lake District & Fjords and cruise the Strait of Magellan, one of the most difficult to navigate paths in all of cruising, yet one of the most rewarding journeys you can undertake. Round Cape Horn and past Tierra del Fuego you may call into the remote Falkland Islands or Puerto Madryn in Patagonia.

Many cruises to South America will include at least one, if not two nights in vibrant, samba-capital of the world, Rio de Janeiro. Home to the carnival, the best football on earth and the incredible 98ft statue of Christ the Redeemer Rio is a an absolute must on anyone's travel "bucket list". Straddling the Argentine-Brazil border is the immense Iguazu Falls, a mighty set of waterfalls which collectively make the largest in the world - it is possible to visit these at the start or end of a South America cruise with an extended land stay.

Ports

South America
Galapagos

We found

326 cruises

MSC Musica, South America
1 / 19
MSC Cruises
Duration
4 nights
Date
16 Nov 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 4 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£559
Price per person / balcony stateroom
AmaMelodia, Magdalena River
1 / 4
AmaWaterways
Duration
7 nights
Date
18 Nov 2026
Ship
AmaMelodia
  • Departure - Cartagena, Colombia
  • 8 stops  
  • Arrival - Barranquilla, Colombia
From
£5084
Price per person / balcony stateroom
Show all departures (34)
MS Santa Cruz II, Galapagos
1 / 22
HX Expeditions
Duration
6 nights
Date
20 Nov 2026
Ship
MS Santa Cruz II
  • Departure - North Seymour Island, Galapagos, Ecuador
  • 12 stops  
  • Arrival - North Seymour Island, Galapagos, Ecuador
From
£7214
Price per person / oceanview stateroom
Show all departures (60)
MSC Musica, South America
1 / 19
MSC Cruises
Duration
3 nights
Date
23 Nov 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£269
Price per person / inside stateroom
Show all departures (3)
MSC Musica, South America
1 / 19
MSC Cruises
Duration
4 nights
Date
26 Nov 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 4 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£319
Price per person / inside stateroom
Show all departures (2)
MS Santa Cruz II, Galapagos
1 / 22
HX Expeditions
Duration
4 nights
Date
26 Nov 2026
Ship
MS Santa Cruz II
  • Departure - North Seymour Island, Galapagos, Ecuador
  • 9 stops  
  • Arrival - North Seymour Island, Galapagos, Ecuador
From
£5159
Price per person / oceanview stateroom
Show all departures (16)
MS Santa Cruz II, Galapagos
1 / 22
HX Expeditions
Duration
8 nights
Date
26 Nov 2026
Ship
MS Santa Cruz II
  • Departure - North Seymour Island, Galapagos, Ecuador
  • 18 stops  
  • Arrival - North Seymour Island, Galapagos, Ecuador
From
£8080
Price per person / oceanview stateroom
Show all departures (60)
MSC Virtuosa, South America
1 / 39
MSC Cruises
Duration
4 nights
Date
28 Nov 2026
Ship
MSC Virtuosa
  • Departure - Salvador de Bahia, Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£1439
Price per person / suite
AmaMagdalena, Magdalena River
1 / 4
AmaWaterways
Duration
7 nights
Date
28 Nov 2026
Ship
AmaMagdalena
  • Departure - Barranquilla, Colombia
  • 8 stops  
  • Arrival - Cartagena, Colombia
From
£5161
Price per person / balcony stateroom
Show all departures (35)
MSC Seaview, South America
1 / 33
MSC Cruises
Duration
3 nights
Date
29 Nov 2026
Ship
MSC Seaview
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£379
Price per person / inside stateroom
MSC Divina, South America
1 / 27
MSC Cruises
Duration
4 nights
Date
29 Nov 2026
Ship
MSC Divina
  • Departure - Santos (São Paulo), Brazil
  • 4 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£439
Price per person / inside stateroom
MSC Musica, South America
1 / 19
MSC Cruises
Duration
3 nights
Date
30 Nov 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£239
Price per person / inside stateroom
MSC Virtuosa, South America
1 / 39
MSC Cruises
Duration
1 night
Date
1 Dec 2026
Ship
MSC Virtuosa
  • Departure - Rio de Janeiro, Brazil
  • 2 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£59
Price per person / inside stateroom
MSC Virtuosa, South America
1 / 39
MSC Cruises
Duration
3 nights
Date
2 Dec 2026
Ship
MSC Virtuosa
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£309
Price per person / oceanview stateroom
MSC Seaview, South America
1 / 33
MSC Cruises
Duration
3 nights
Date
2 Dec 2026
Ship
MSC Seaview
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£359
Price per person / balcony stateroom
MSC Musica, South America
1 / 19
MSC Cruises
Duration
3 nights
Date
3 Dec 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£239
Price per person / inside stateroom
Show all departures (3)
MSC Splendida, South America
1 / 29
MSC Cruises
Duration
3 nights
Date
3 Dec 2026
Ship
MSC Splendida
  • Departure - Buenos Aires, Argentina
  • 2 stops  
  • Arrival - Rio de Janeiro, Brazil
From
£619
Price per person / balcony stateroom
MSC Splendida, South America
1 / 29
6 % off
MSC Cruises
Duration
8 nights
Date
3 Dec 2026
Ship
MSC Splendida
  • Departure - Buenos Aires, Argentina
  • 6 stops  
  • Arrival - Buenos Aires, Argentina
£789
From
£742
Price per person / oceanview stateroom
Show all departures (8)
MSC Virtuosa, South America
1 / 39
MSC Cruises
Duration
4 nights
Date
5 Dec 2026
Ship
MSC Virtuosa
  • Departure - Santos (São Paulo), Brazil
  • 4 stops  
  • Arrival - Maceió, Brazil
From
£301
Price per person / inside stateroom
Show all departures (2)
MSC Virtuosa, South America
1 / 39
MSC Cruises
Duration
3 nights
Date
5 Dec 2026
Ship
MSC Virtuosa
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Salvador de Bahia, Brazil
From
£339
Price per person / inside stateroom
20 of 326 pcs